AKAP11

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.[5][6][7]

AKAP11
Identifiers
Aliases	AKAP11, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs	OMIM: 604696 MGI: 2684060 HomoloGene: 8279 GeneCards: AKAP11
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 42,272,152 bp[1] End 42,323,261 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 78,492,246 bp[2] End 78,536,808 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase 1 binding • protein kinase A binding • GO:0001948 protein binding Cellular component • cytoplasm • peroxisome • cytoskeleton • microtubule organizing center • nucleolus • cytosol • cell membrane Biological process • GO:0007243 intracellular signal transduction • regulation of protein kinase A signaling • protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11215	219181
Ensembl	ENSG00000023516	ENSMUSG00000022016
UniProt	Q9UKA4	n/a
RefSeq (mRNA)	NM_016248 NM_144490	NM_001164503 NM_001346784
RefSeq (protein)	NP_057332	n/a
Location (UCSC)	Chr 13: 42.27 – 42.32 Mb	Chr 14: 78.49 – 78.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.[7]

Interactions

AKAP11 has been shown to interact with:

• GSK3B,[8]
• PPP1CA,[8][9]
• PRKAR2A,[6][8][10]
• PRKAR2B.[11]
• VAPB.[12] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3. [13]

References

1. GRCh38: Ensembl release 89: ENSG00000023516 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022016 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF). J. Biol. Chem. 271 (16): 9460–5. doi:10.1074/jbc.271.16.9460. PMID 8621616.
7. "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
8. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi:10.1074/jbc.M206210200. PMID 12147701.
9. Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
10. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
11. Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi:10.1006/dbio.2000.9725. PMID 10864471.
12. Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi:10.1016/j.cell.2015.06.043. PMC 4617211. PMID 26186194.
13. Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2". PLOS ONE. 7 (1): e30455. doi:10.1371/journal.pone.0030455. PMC 3261905. PMID 22276202.

External links

• Human AKAP11 genome location and AKAP11 gene details page in the UCSC Genome Browser.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
• Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi:10.1006/dbio.2000.9725. PMID 10864471.
• Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD (2001). "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation". J. Biol. Chem. 276 (15): 12128–34. doi:10.1074/jbc.M010398200. PMID 11152471.
• Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. doi:10.4049/jimmunol.168.4.1590. PMID 11823486.
• Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi:10.1074/jbc.M206210200. PMID 12147701.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.