AGR3

Anterior gradient protein 3 homolog is a protein that in humans is encoded by the AGR3 gene.[5][6][7]

AGR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PH9
Identifiers
Aliases	AGR3, AG3, BCMP11, HAG3, PDIA18, hAG-3, AG-3, anterior gradient 3, protein disulphide isomerase family member
External IDs	OMIM: 609482 MGI: 2685734 HomoloGene: 45551 GeneCards: AGR3
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.1 Start 16,859,412 bp[1] End 16,881,987 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A3 Start 35,925,620 bp[2] End 35,949,736 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • dystroglycan binding Cellular component • endoplasmic reticulum • cellular component • intracellular membrane-bounded organelle Biological process • cell differentiation • negative regulation of cell death • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	155465	403205
Ensembl	ENSG00000173467	ENSMUSG00000036231
UniProt	Q8TD06	Q8R3W7
RefSeq (mRNA)	NM_176813	NM_207531
RefSeq (protein)	NP_789783	NP_997414
Location (UCSC)	Chr 7: 16.86 – 16.88 Mb	Chr 12: 35.93 – 35.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173467 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036231 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA (Feb 2003). "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan". British Journal of Cancer. 88 (4): 579–85. doi:10.1038/sj.bjc.6600740. PMC 2377166. PMID 12592373.
6. Adam PJ, Boyd R, Tyson KL, Fletcher GC, Stamps A, Hudson L, Poyser HR, Redpath N, Griffiths M, Steers G, Harris AL, Patel S, Berry J, Loader JA, Townsend RR, Daviet L, Legrain P, Parekh R, Terrett JA (Feb 2003). "Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer". The Journal of Biological Chemistry. 278 (8): 6482–9. doi:10.1074/jbc.M210184200. PMID 12477722.
7. "Entrez Gene: AGR3 anterior gradient homolog 3 (Xenopus laevis)".

External links

• Human AGR3 genome location and AGR3 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Persson S, Rosenquist M, Knoblach B, Khosravi-Far R, Sommarin M, Michalak M (Sep 2005). "Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family". Molecular Phylogenetics and Evolution. 36 (3): 734–40. doi:10.1016/j.ympev.2005.04.002. PMID 15935701.