ADAMTSL4

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.[5][6]

ADAMTSL4
Identifiers
Aliases	ADAMTSL4, ADAMTSL-4, ECTOL2, TSRC1, ADAMTS like 4
External IDs	OMIM: 610113 MGI: 2389008 HomoloGene: 23141 GeneCards: ADAMTSL4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,549,369 bp[1] End 150,560,937 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,676,201 bp[2] End 95,687,917 bp[2]
Gene ontology Molecular function • protease binding • peptidase activity • GO:0001948 protein binding Cellular component • extracellular region • interstitial matrix • endoplasmic reticulum lumen • cellular component • extracellular matrix • collagen-containing extracellular matrix Biological process • positive regulation of apoptotic process • extracellular matrix organization • proteolysis • apoptotic process • epithelial cell development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54507	229595
Ensembl	ENSG00000143382	ENSMUSG00000015850
UniProt	Q6UY14	Q80T21
RefSeq (mRNA)	NM_001288607 NM_001288608 NM_019032 NM_025008 NM_001378596	NM_001301705 NM_144899
RefSeq (protein)	NP_001275536 NP_001275537 NP_061905 NP_079284 NP_001365525	NP_001288634 NP_659148
Location (UCSC)	Chr 1: 150.55 – 150.56 Mb	Chr 3: 95.68 – 95.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015850 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Buchner DA, Meisler MH (Mar 2003). "TSRC1, a widely expressed gene containing seven thrombospondin type I repeats". Gene. 307: 23–30. doi:10.1016/S0378-1119(03)00423-2. PMID 12706885.
6. "Entrez Gene: ADAMTSL4 ADAMTS-like 4".

Further reading

• Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Developmental Dynamics. 218 (2): 280–299. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–15729. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY (Jan 2006). "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90". FEBS Letters. 580 (1): 245–250. doi:10.1016/j.febslet.2005.12.005. PMID 16364318. S2CID 8768006.

External links

• GeneReviews/NCBI/NIH/UW entry on ADAMTSL4-Related Eye Disorders,Autosomal Recessive Isolated Ectopia Lentis,Ectopia Lentis et Pupillae
• Human ADAMTSL4 genome location and ADAMTSL4 gene details page in the UCSC Genome Browser.