A-1,6-mannosyl-glycoprotein 6-b-N-acetylglucosaminyltransferase

Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155, N-acetylglucosaminyltransferase V, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase, UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, GnTV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
Identifiers
EC number2.4.1.155
CAS number83588-90-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References
  1. Cummings RD, Trowbridge IS, Kornfeld S (November 1982). "A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 257 (22): 13421–7. PMID 6216250.
  2. Hindsgaul O, Tahir SH, Srivastava OP, Pierce M (March 1988). "The trisaccharide beta-D-GlcpNAc-(1----2)-alpha-D-Manp-(1----6)-beta-D-Manp, as its 8-methoxycarbonyloctyl glycoside, is an acceptor selective for N-acetylglucosaminyltransferase V". Carbohydrate Research. 173 (2): 263–72. doi:10.1016/s0008-6215(00)90822-x. PMID 2834054.
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