4-hydroxybenzoate polyprenyltransferase

In enzymology, a 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39) is an enzyme that catalyzes the chemical reaction

a polyprenyl diphosphate + 4-hydroxybenzoate diphosphate + a 4-hydroxy-3-polyprenylbenzoate
4-hydroxybenzoate polyprenyltransferase
Identifiers
EC number2.5.1.39
CAS number9030-77-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are a polyprenyl diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and 4-hydroxy-3-polyprenylbenzoate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme participates in ubiquinone biosynthesis.[1]

Nomenclature

The systematic name of this enzyme class is polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase. Other names in common use include:

  • nonaprenyl-4-hydroxybenzoate transferase,
  • 4-hydroxybenzoate transferase,
  • p-hydroxybenzoate dimethylallyltransferase,
  • p-hydroxybenzoate polyprenyltransferase,
  • p-hydroxybenzoic acid-polyprenyl transferase,
  • p-hydroxybenzoic-polyprenyl transferase, and
  • 4-hydroxybenzoate nonaprenyltransferase

References

  1. Melzer M, Heide L (1994-04-14). "Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli". Biochim Biophys Acta. 1212 (1): 93–102. doi:10.1016/0005-2760(94)90193-7. PMID 8155731.
  • Kalen A, Appelkvist EL, Chojnacki T, Dallner G (1990). "Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver". J. Biol. Chem. 265 (2): 1158–64. PMID 2295606.


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