3-Hydroxybutyrate dehydrogenase
In enzymology, 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) is an enzyme that catalyzes the chemical reaction:
| 3-Hydroxybutyrate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.30 | ||||||||
| CAS number | 9028-38-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD+, whereas its three products are acetoacetate, NADH, and H+. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.
This enzyme participates in the synthesis and degradation of ketone bodies and the metabolism of butyric acid.
Synonyms
The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD+ oxidoreductase. Other names in common use include:
- NAD+-β-hydroxybutyrate dehydrogenase
- hydroxybutyrate oxidoreductase
- β-hydroxybutyrate dehydrogenase
- D-β-hydroxybutyrate dehydrogenase
- D-3-hydroxybutyrate dehydrogenase
- D-(–)-3-hydroxybutyrate dehydrogenase
- β-hydroxybutyric acid dehydrogenase
- 3-D-hydroxybutyrate dehydrogenase
- β-hydroxybutyric dehydrogenase
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.
See also
References
- Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH (1967). "Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides". Biochem. J. 102 (2): 423–31. doi:10.1042/bj1020423. PMC 1270263. PMID 4291491.
- Delafield FP, Cooksey KE, Doudoroff M (1965). "beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei". J. Biol. Chem. 240 (10): 4023–8. PMID 4954074.
- Lehninger AL, Sudduth HC, Wise JB (1960). "D-beta-Hydroxybutyric dehydrogenase of mitochondria". J. Biol. Chem. 235: 2450–2455. PMID 14415394.
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