23S rRNA (cytosine1962-C5)-methyltransferase

23S rRNA (cytosine1962-C5)-methyltransferase (EC 2.1.1.191, RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine1962 in 23S rRNA S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA
23S rRNA (cytosine1962-C5)-methyltransferase
Identifiers
EC number2.1.1.191
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA.

References

  1. Purta E, O'Connor M, Bujnicki JM, Douthwaite S (November 2008). "YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962". Journal of Molecular Biology. 383 (3): 641–51. doi:10.1016/j.jmb.2008.08.061. PMID 18786544.
  2. Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J (November 2008). "Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes". Journal of Molecular Biology. 383 (3): 652–66. doi:10.1016/j.jmb.2008.08.062. PMID 18789337.
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